Informant38

AIS-Introduction People with AIS have a functioning Y chromosome (and therefore no female internal organs), but an abnormality on the X chromosome that renders the body completely or partially incapable of recognising the androgens produced. In the case of complete androgen insensitivity (CAIS) the external genital development takes a female form. In the case of partial insensitivity (PAIS) the external genital appearance may lie anywhere along the spectrum from male to female. Other related conditions, resulting from changes on different chromosomes, also disrupt the normal pathway of androgen action, resulting again in a feminized phenotype (external body form). People with these conditions may identify as female, intergendered, or male